Novel protein trafficking and signaling pathways in kidney physiology and pathophysiology
Abstract
The nephron's fluid and electrolyte transport properties are determined largely by the inventories of ion transport proteins occupying the apical and basolateral plasma membrane domains of renal tubule epithelial cells. The asymmetric apportioning of ion channels, transporters and pumps among these domains determines the nature of the fluxes maintained by renal epithelia. Generation and maintenance of differentiated plasmalemmal domains requires a cell to possess machinery capable of discriminating among newly synthesized membrane proteins. Information embedded in these proteins' structures serves as sorting signals that specify their appropriate destinations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1096/fasebj.2019.33.1_supplement.20.2
Entities
People
- Christina W. Olesen
- Giorgia Schena
- Kavita Mistry
- Michael J Caplan
- Nikolay Gresko
- Rosalie Bateson
- Valeria Padovano
Organizations
- National Institute of Diabetes and Digestive and Kidney Diseases
- United States Department of Defense
- Yale University