Acute Spinal Cord Injury Causes Cardiac Contractile Dysfunction that when Treated Aids Spinal Cord Oxygenation
Abstract
In chronically injured humans and rodents with spinal cord injury (SCI) cardiac function is impaired. It is unknown whether such dysfunction is present acutely post‐SCI and if so whether it contributes to reduced spinal cord oxygenation. The aims of the present study, therefore, were to 1) define the acute cardiac and hemodynamic response to SCI, and 2) test the efficacy of a cardiac‐centered hemodynamic management strategy (β1‐receptor agonist dobutamine, DOB) vs. a traditional vasopressor‐based strategy (norepinephrine, NE) on intraparenchymal spinal cord oxygenation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1096/fasebj.2019.33.1_supplement.531.9
Entities
People
- Alex H Williams
- Brian K Kwon
- Christopher R West
- Femke Streijger
- Katelyn Shortt
- Keerit Tauh
- Kitty So
- Malihe Poormasjedi‐meibod
- Neda Manouchehri
- Robert Boushel
Organizations
- Michael Smith Foundation for Health Research
- Rick Hansen Institute
- United States Department of Defense
- University of British Columbia