A Hydrogen Sulfide Donor NSAID Influences Inflammatory Cell Responses Following Exertional Heat Stroke
Abstract
One of the consequences of exposure to exertional heat stroke (EHS) is marked damage to the GI tract. GI damage is believed to promote EHS‐induced activation of the immune system and to be a major contributor to the morbidity and mortality of EHS. We hypothesized that the use of non‐steroidal anti‐inflammatory drugs (NSAIDS), so commonly used in exercising humans, would amplify this damage, make subjects more susceptible to EHS and result in greater GI damage and inflammation. We also hypothesized that the use of next generation NSAIDs containing a hydrogen sulfide (H2S) donor, shown to protect the GI tract, would suppress the damaging effects of unmodified NSAIDs. In this study we focus on the impact of both forms of NSAIDs on immune cell populations in the blood following EHS. To test this, we utilized a preclinical mouse model of EHS in mice, previously developed in our laboratory.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1096/fasebj.2019.33.1_supplement.764.4
Entities
People
- Christian Garcia
- Gerard Robinson
- John Iwaniec
- Kevin O Murray
- Laila Sheikh
- Orlando Laitano
- Reed Berlet
- Thomas L Clanton
Organizations
- United States Department of Defense
- University of Florida