Tracking DO2 with Compensatory Reserve during Whole Blood Resuscitation in Baboons
Abstract
Hemorrhagic shock can be mitigated by timely and accurate resuscitation designed to restore adequate delivery of oxygen (DO2) by increasing cardiac output (CO). However, standard care of using systolic blood pressure (SBP) as a guide for resuscitation has proven ineffective and can be associated with increased morbidity. We have developed a novel vital sign called the compensatory reserve (CRM) generated from analysis of arterial pulse waveform feature changes that has been validated in experimental and clinical models of hemorrhage. We tested the hypothesis that thresholds of DO2 could be accurately defined by CRM while avoiding over resuscitation during whole blood resuscitation following a 25% hemorrhage in non‐human primates.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1096/fasebj.2019.33.1_supplement.840.2
Entities
People
- Betty Nguyen
- Carmen Hinojosa‐laborde
- Natalie Jane Koons
- Víctor A. Convertino
Organizations
- United States Army Medical Research and Development Command
- United States Department of Energy