Epigenetic Memory and Phenotype Change Observed in Mouse Skeletal Muscle 30 Days after Exertional Heat Stroke
Abstract
Exposure to exercise and extreme environments, such as exertional heat stroke (EHS), can induce a long‐term epigenetic memory of stress that is stored as altered DNA‐methylation and/or histone posttranslational modifications. These changes can ultimately affect gene and protein expression as well as cellular function, which may lead to greater disease susceptibility. Previously, we have observed that a single bout of EHS can drastically alter the DNA methylome in monocytes lasting up to 30 days; however, whether these epigenetic changes are reflected in skeletal muscle has not been characterized.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1096/fasebj.2019.33.1_supplement.842.5
Entities
People
- Christian Garcia
- Gerard Robinson
- John Iwaniec
- Kevin O Murray
- Laila Sheikh
- Orlando Laitano
- Rasha Hammamieh
- Ross Campbell
- Ruoting Yang
- Thomas L Clanton
Organizations
- U.S. Army Center for Environmental Health Research
- United States Department of Defense
- University of Florida