Ibuprofen effects on the response to exertional heat stroke in male and female mice
Abstract
One of the major risks of exertional heat stroke (EHS) is increased intestinal damage. Further intestinal damage may be exacerbated while using non‐steroidal anti‐inflammatory drugs (NSAIDs) in the heat. Ibuprofen (IBU) is the most commonly used NSAID in the United States. It is an inhibitor of both COX‐1 and COX‐2, decreasing prostaglandins involved in the maintenance of the intestinal lining, induction of fever, and platelet aggregation. Using a preclinical model of EHS, we investigated the effects of ibuprofen on performance and intestinal damage in a hyperthermic environment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1096/fasebj.2019.33.1_supplement.842.6
Entities
People
- Alex Mattingly
- Christian Kyle Garcia
- Gerard P. Robinson
- John D. Iwaniec
- Kevin O Murray
- Laila H. Sheikh
- Orlando Laitano
- Reed A Berlet
- Thomas L Clanton
Organizations
- United States Department of Defense
- University of Florida