Effects of Vasopressin and Norepinephrine on Wound Healing of Vascular Smooth Muscle and Endothelium
Abstract
Hemorrhagic shock as a result of trauma or surgical bleeding is frequently temporized with administration of vasopressors in order to augment systemic vascular resistance while resuscitation measures are employed. This mimics the treatment strategy of other forms of shock where systemic vascular resistance is low and vasopressors are heavily relied upon to resuscitate the patient. Blood vessels respond to direct exposure to vasopressin and norepinephrine via receptors on smooth muscle and endothelial cells and ultimately result in vasoconstriction which contributes to a low flow state and increases shear stress within vessels. The effect of vasopressors on vascular cells with regard to direct cellular injury and repair has not been well‐studied. The objective of this study is to examine the in vitro effect of vasopressin and norepinephrine on the rate of healing of vascular cells after wounding.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1096/fasebj.2019.33.1_supplement.lb517
Entities
People
- Dao H. Ho
- Kenneth J Bogenberger
Organizations
- Tripler Army Medical Center
- United States Army Medical Command