Human Colonoids Enable the Study of Host‐Specific Infectivity and Proteomic Responses to Campylobacter jejuni Infection
Abstract
Immortalized cell lines are conventionally used to examine bacterial virulence and host responses. These models lack heterogeneity, complexity and do not allow interrogation of host specific characteristics. Human intestinal organoids provide a model of human epithelium and allow determination of whether bacterial infections elicit host dependent responses.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2022
- Source ID
- 10.1096/fasebj.2022.36.s1.l7950
Entities
People
- Adam Edwinson
- Gianrico Farrugia
- Madhusudan Grover
- Maggie Breen‐lyles
- Surendra Dasari
Organizations
- Mayo Clinic
- United States Department of Defense