Long‐term myocardial DNA methylation and metabolomic responses to exertional heat stroke in mice
Abstract
Epidemiological studies indicate that exposure to exertional heat stroke (EHS) can increase the risk of all‐cause cardiovascular and systemic disease and promote early mortality. Using a preclinical mouse model of EHS, we previously characterized profound DNA methylation changes in immune cells at 30 d of recovery and severe cardiometabolic disturbances in the ventricular myocardium (VM) at 9‐14 d. These observations indicate that a single exposure to EHS can result in long‐term epigenetic and metabolic alterations. However, whether a long‐term epigenetic responses occur in the VM and or whether cardiometabolic perturbations persist is unknown.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2022
- Source ID
- 10.1096/fasebj.2022.36.s1.r3770
Entities
People
- Jason O. Brant
- Kevin O Murray
- Michael P. Kladde
- Thomas L Clanton
Organizations
- United States Army
- University of Florida