Lower blood pressure, but not muscle sympathetic nerve activity, in female compared to male adults during progressive central hypovolemia
Abstract
Rapid adjustments in cardiac output and sympathetically‐mediated vasoconstriction are critical to prevent blood pressure (BP) from falling during central hypovolemia. Female adults have a reduced ability to tolerate central hypovolemia (i.e., orthostatic hypotension), potentially due to reduced sympathetically‐mediated vasoconstriction. However, there are minimal data evaluating sex differences in muscle sympathetic nerve activity (MSNA) during pre‐syncopal limited central hypovolemia. Therefore, the purpose of this study was to compare autonomic cardiovascular responses during central hypovolemia between sexes. We tested the hypothesis that young healthy female, compared to male, adults would have a lower tolerance to progressive hypovolemia, accompanied by attenuated MSNA responses.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2022
- Source ID
- 10.1096/fasebj.2022.36.s1.r5117
Entities
People
- Caitlin P. Jarrard
- Claire E. Trotter
- Craig G Crandall
- Joseph C Watso
- Mu Huang
Organizations
- National Institutes of Health
- Southern Methodist University
- United States Department of Defense
- University of Texas Southwestern Medical Center