A New Model of Exertional Heat Stroke in Male Mice Reveals Sustained Metabolic Dysfunction in the Myocardium
Abstract
Exertional heat stroke (EHS) is a life threating condition that has grown in prevalence with rising global temperatures. Development and use of new preclinical models are necessary to understand the pathophysiology. In our previous model of EHS, a metabolic disorder occurred in the ventricular myocardium (VM) after 14 days of recovery only in female mice. However, females were able to achieve much higher levels of exercise than males. In this study we developed a new model, specific for male mice, that prolonged exercise time and intensity but at a lower environmental temperature (Te). We then tested whether this approach would induce similar metabolic disorders of the VM in male hearts that was seen previously in females.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2022
- Source ID
- 10.1096/fasebj.2022.36.s1.r5951
Entities
People
- Bryce J. Gambino
- Christian K. Garcia
- Cristina D. Delgado
- Gerard P. Robinson
- Jamal M. Alzahrani
- Kevin J. Cusack
- Michael T. Rua
- Thomas L Clanton
Organizations
- United States Army
- University of Florida