Diurnal pattern in endogenous insulin secretion persists in severely injured patients
Abstract
Intensive insulin therapy decreases mortality due to critical illness but glucose and insulin variability pose a challenge to tight glucose control. We previously demonstrated that circadian rhythms in glucose and exogenous insulin requirement are preserved, and hypothesized that similar patterns in endogenous insulin secretion are also present.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2008
- Source ID
- 10.1096/fasebj.22.1_supplement.1205.7
Entities
People
- Charles E Wade
- Heather Pidcoke
- John A. Jones
- John B Holcomb
- Steven E. Wolf
Organizations
- JDRF
- National Institutes of Health
- United States Army Medical Research and Development Command
- University of Texas at Austin