Adenosine Indexes RyR1‐Agonist‐Induced Calcium Overload In Lymphocytes from Malignant Hyperthermia (MH) Susceptible (MHS) Patients
Abstract
The RyR1 receptor exists in human blood lymphocytes (B‐cells); RyR1 agonists can induce calcium overload in B‐cells from MHS individuals. We hypothesized that RyR1‐agonism is associated with increased adenosine (ADO) formation due to increased ATP degradation, which is enhanced in B‐cells from MHS subjects.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2009
- Source ID
- 10.1096/fasebj.23.1_supplement.991.2
Entities
People
- John Capacchione
- Rolf Bunger
- Saiid Bina
- Sheila Muldoon
Organizations
- Uniformed Services University of the Health Sciences