Persistence of Lactobacillus Reuteri DSM17938 in the Human Intestinal Tract
Abstract
Probiotics may enhance gastrointestinal health and immune function. The efficacy of different dosing strategies on colonization and persistence of probiotics are undefined. We assessed colonization and persistence of Lactobacillus reuteri (L. reuteri) (BioGaia, Stockholm, Sweden) after daily or alternate day dosing. Volunteers ate pudding with L. reuteri (109 CFU) daily (DAILY; n = 9) or on alternate days (ALT; n = 9) over 7 days. Fecal samples were collected on dosing days (D1–7) and after dosing ended (D13–15 and D20–22), and analyzed for L. reuteri. Results are reported in 3‐day increments (D2–4, D5–7, D13–15, and D20–22). L. reuteri count rose in DAILY ([mean ± SD] D2–4: 4 × 104 ± 2 × 104CFU, p 4 ± 9 × 104CFU, p 4± 20 × 104CFU, p 4± 15 × 104CFU, P = 0.06), and fell in both groups 1 week after dosing ended (p L. reuteri 1 and 2 weeks after dosing ended was similar for DAILY (4/9 and 2/9, respectively) and ALT (3/9 and 2/9, respectively). L. reuteri count was higher D2–4 for ALT vs. DAILY (p Funded by MRMC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2010
- Source ID
- 10.1096/fasebj.24.1_supplement.340.1
Entities
People
- Andrew J Young
- Anthony Sikes
- Danielle E Anderson
- Lee M. Margolis
- Tracey J. Smith
Organizations
- United States Army Medical Research and Development Command
- United States Army Research Institute of Environmental Medicine