Inter‐ and intra‐strain variability for survival time after hemorrhage in inbred rats
Abstract
In an effort to identify genes influencing survival time after hemorrhage (STaH) we earlier reported 8‐fold differences in STaH among 15 inbred rat strains, indicating a genetic basis for STaH (Klemcke et al., Shock 29:748, 2008). Subsequently, we identified that the inbred rat strains differed in blood volume (BV) which could account for differences in STaH. Thus, to re‐address the question of genetic influences on STaH, 5 inbred rat strains [Brown Norway (BN/Mcwi, n=9), Dark Agouti (DA, n=8), Fawn Hooded Hypertensive (FHH, n=10), Lewis (Lew, n=9) and Salt Sensitive (SS, n=9)] were bled using strain specific BVs. For each rat, 47% of its BV was removed and STaH was measured. Threefold differences for STaH among the strains (pTable). Rats of an inbred strain are genetically very similar with a small degree of genetic variability. Thus, it was of interest to observe considerable intra‐strain variation for STaH (Table).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2010
- Source ID
- 10.1096/fasebj.24.1_supplement.lb697
Entities
People
- Harold G. Klemcke
- Mariam Calderon
- Rajiv Rose
- Taesung Oh
Organizations
- United States Army Institute of Surgical Research
- United States Army Medical Research and Development Command