Recombinant erythropoietin administration reduces exercise‐induced deline in regional cerebral oxygenation at 4500 m
Abstract
At high altitude, exercise‐induced arterial desaturation decreases regional cerebral oxygenation (rO2Hb). Erythropoietin (EPO) potentiates endothelium‐mediated dilation of isolated, perfused rat middle cerebral arteries. To determine if EPO administration in humans mitigated the decreased cerebral rO2Hb during exercise within the first 3 h at 4500 m eight healthy male lowlanders received a subcutaneous injection of either EPO (600 IU/Kg) or a placebo (PLA) (0.9% NaCl) ~12 hr prior to ascent in a hypobaric chamber in a double‐blind, cross‐over study. We measured frontal lobe rO2 Hb by NIRS, arterial saturation (SaO2) by pulse oximetry, and PetO2 and PetCO2 by metabolic cart during rest and 50 W cycling. At 4500 m, serum EPO levels were (mean ± SD) 6 ± 2 and 720 ± 273 mU/ml for PLA and EPO trials, respectively. From rest‐to‐ exercise SaO2 decreased similarly in both trials (PLA: −6 ± 4 and EPO: −8 ± 4%), but rSO2 declined less in EPO (PLA: −2.12 ± 1.93 and EPO: −1.47 ± 2.40 μM, p=0.027), while rest and exercise PetO2 and PetCO2 were similar for both trials.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2012
- Source ID
- 10.1096/fasebj.26.1_supplement.1150.1
Entities
People
- Beth A. Beidleman
- Charles S. Fulco
- Janet E. Staab
- Juli E. Jones
- Stephen Raymond Muza
Organizations
- United States Army Medical Research and Development Command
- United States Army Research Institute of Environmental Medicine