Lower prediagnostic serum 25‐hydroxyvitamin D concentration is associated with increased incidence of type 1 diabetes in the U. S. military: a nested case‐control study
Abstract
Low serum 25‐hydroxyvitamin D (25(OH)D) concentration may increase risk of Type 1 diabetes. This is the first study to describe an inverse association of 25(OH)D with Type 1 diabetes incidence, using serum collected before diagnosis. A nested case‐control study was done using serum collected during 2002–2008 from service members. 1000 subjects subsequently developed Type 1 diabetes. A healthy control was individually matched to each case on blood draw date (± 2 days), age (± 3 months), length of service (± 30 days), and gender. Matched pairs and conditional logistic regression were performed. Odds ratios for Type 1 diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI, 2.0–6.0), 2.5 (1.5–4.2), 0.8 (0.4–1.4), 1.1 (0.6–2.8) and 1.0 (reference) (p trend 70 nmol/L is consistent with 4,000 IU/d tolerable intake of vitamin D at ages ≥ 9 years, according to a 2011 National Academy of Sciences monograph. A proposed model is outlined that could explain the inverse association of 25(OH)D with Type 1 diabetes, the DIAB epithelial barrier model. Supported by NHRC Work Unit 60126. Thanks to Dr. Angelee Eick, AFHSC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2012
- Source ID
- 10.1096/fasebj.26.1_supplement.41.3
Entities
People
- Alina Burgi
- Camillo Ricordi
- Cedric Frank Garland
- Edward Doerr Gorham
- Heather Hofflich
- Kenneth Zeng
- Sharif Burgette Mohr
Organizations
- Naval Health Research Center
- University of California, San Diego
- University of Miami