Changes in mouse serotonin and dopamine receptor labeling in the intermediolateral nucleus after spinal cord injury
Abstract
Autonomic dysreflexia (AD), a neurological condition associated with spinal cord injury (SCI), is a hypertensive crisis initiated following activation of peripheral pain fibers. As descending monoaminergic neuromodulatory transmitter systems project densely to thoracic spinal cord sympathetic preganglionic regions, lost connections after SCI may contribute to altered autonomic function. Using immunohistochemistry (IHC), this study examined the distributions of three receptors; serotonergic 5HT2A, and dopaminergic D2 and D3 in the intermediolateral nucleus (IML), the location of sympathetic preganglionic neurons (SPNs) in a mouse model of AD. Labeling was explored in control cords at ~P70, and in littermates 3 weeks following spinalization at high thoracic levels (T1/T2). Analysis focused on SPNs in the IML, efferent neurons that are presumably responsible for blood pressure increases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2012
- Source ID
- 10.1096/fasebj.26.1_supplement.902.1
Entities
People
- Amanda Zimmerman
- Brannan Elizabeth O'neill
- Michael Sawchuk
- Shawn Hochman
Organizations
- Emory University
- United States Department of Defense