Potassium channels on natural killer cells in the presence of breast carcinoma cells
Abstract
Natural Killer (NK) cells are cytotoxic lymphocytes that play an important role in immune defense against viruses and cancer. Reduced NK cell activity has been associated with tumor resistance and metastasis in breast cancer. Our overall objective is to determine the phenotype and function of potassium channels on human NK cells in presence of breast cancer cells. We have found that human NK cells express two types of potassium channels, namely Kv1.3 and KCa3.1. The potassium channel phenotype did not vary with expression levels of CD16 and CD56 but it did differ between adherent and non‐adherent NK cells following cytokine‐induced activation. Blocking Kv1.3 and KCa3.1 channels differentially affected the proliferation, degranulation, and adhesion to fibronectin and tumor cells by adherent and non‐adherent human NK cells in vitro and differentially affected their ability to destroy tumors in vivo.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2012
- Source ID
- 10.1096/fasebj.26.1_supplement.966.4
Entities
People
- Abiola Odejimi
- Christine Beeton
- Danli Wu
- Patricia Yotnda
- Rajeev Tajhya
- Shyny Koshy
- Xueyou Hu
Organizations
- American Heart Association
- Baylor College of Medicine
- United States Department of Defense