Regulation of the browning of human white adipose: evidence for sympathetic control and sexual dimorphic responses to sprint interval training (1160.4)
Abstract
The conversion of white to thermogenic beige adipose tissue has been proposed as an obesity treatment. 3 regulators of this conversion have emerged but information regarding their control is limited. We present 2 studies examining control of these regulators. Study 1: In 10 men, plasma irisin and fibroblast growth factor 21 (FGF21) concentrations were determined prior‐to/during sympathetic activation via hypoxic gas breathing (FIO2=0.11). The measurements were performed twice: with and without sympathetic inhibition (clonidine). FGF21 was unaffected by basal sympathetic inhibition (338±113 vs. 295±80 pg/mL; P=0.43; mean±SE), but was increased during sympathetic activation (368±135); clonidine abrogated this response (269±93; P=0.035). Irisin was unaffected by sympathetic inhibition and/or hypoxia (P>0.21). Study 2: Plasma irisin and FGF21 concentrations, and skeletal muscle protein content of fibronectin type III domain containing 5 (FNDC5) was determined in 19 adults pre/post 3 weeks of sprint interval training (SIT). SIT decreased FGF21 (338±78 vs. 251±36; P=0.046) but did not affect FNDC5 (P=0.79). Irisin was decreased in males (127±18 vs. 90±23 ng/mL; P=0.045) and increased in females (139±14 vs. 170±18). These data suggest a regulatory role of acute sympathetic activation pertaining to the browning of white adipose; further, there appears to be a sexual dimorphic response of irisin to SIT.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.1160.4
Entities
People
- Anna Klochak
- Christopher Bell
- Dennis Larson
- Garrett Peltonen
- Gary Luckasen
- Gregory Giordano
- Hunter Paris
- Lacey Wood
- Matthew Hickey
- Melani Schweder
- Rebecca L Scalzo
- Scott Binns
- Steve Szallar
Organizations
- Colorado State University
- Defense Advanced Research Projects Agency