Ambulatory moderate plus vigorous physical activity is associated with greater bone mineral density in the hip in children with Prader‐Willi syndrome (1166.2)
Abstract
Individuals with Prader‐Willi Syndrome (PWS) present hypotonia, low lean mass and a fairly low amount of spontaneous ambulatory physical activity (PA), possibly influencing bone mineral density (BMD). This study explored the differences in BMD between more and less active children with PWS. Twenty five children with PWS participated (age: 10.8±2.0 y, height: 141.4±11.7 cm, lean mass [LM]: 28.32±10.31 kg). Moderate plus vigorous PA (MVPA) was assessed via accelerometry. Participants were categorized into more active (n=13, MVPA: 44±3 min/day) and less active (n=12, MVPA: 23±2 min/day) groups based on a MVPA median split of 33 min/day. LM, bone mineral content (BMC), BMD and BMD z‐score (BMDz) of the hip, spine and total body minus the head were measured by dual energy x‐ray absorptiometry. Group differences were assessed using analyses of covariance, controlling for age, height and LM depending on the model. More active children had a significantly greater hip BMD (0.86±0.03 vs. 0.76±0.03 g/cm2), BMDz (0.28±0.28 vs. ‐0.86±0.29) and BMC (19.37±0.72 vs. 17.20±0.75 g) than their less active peers (p<0.05). There were no significant group differences for any spine or total body bone parameters. Children with PWS should incorporate moderate plus vigorous weight‐bearing activities as a critical component of their daily routine.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.1166.2
Entities
People
- Andrea Duran
- Daniela Rubin
- Diobel M Castner
- Jared Tucker
Organizations
- California State University