Site‐specific variation in cortical porosity and histomorphometry as a reflection of growth and mechanical adaptation in the human tibia (541.12)
Abstract
Previous research has shown that individuals with more slender (narrow relative to length) tibiae may suppress remodeling as a means of increasing tissue stiffness. To test this hypothesis, we quantified cortical porosity (using µCT) and histomorphometry (using light microscopy) in human cadaveric tibia samples (N=10; obtained from 38% and 66% distance proximal to distal endplate) and examined correlations with robustness (total cross‐sectional area/length) and elastic modulus (determined by finite element analysis). Data were analyzed for whole cross‐sections and by anatomically determined regions of interest (ROIs) to determine site‐specific variability.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.541.12
Entities
People
- Chamith Rajapakse
- David C Lin
- Haviva Goldman
- J Guth
- Karl Jepsen
- Lindsey Kent
- Naomi Hampson
Organizations
- Drexel University
- United States Department of Defense
- University of Michigan
- University of Pennsylvania