Splicing regulation of alternative exon 23a of the neurofibromatosis type 1 pre‐mRNA by DBIRD complex (560.5)
Abstract
Hu proteins are neuron‐enriched RNA‐binding proteins that regulate alternative splicing by binding to AU‐rich sequences of pre‐mRNAs. Recently, we showed that Hu proteins participate in epigenetic regulation of the Neurofibromatosis type 1 (NF1) exon 23a splicing by directly interacting with HDAC2 and inhibiting its deacetylation activity to induce local histone hyperacetylation surrounding exon 23a, leading to increased local transcriptional elongation rate and decreased exon inclusion (Zhou et al., PNAS, 2011).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.560.5
Entities
People
- Hieu T. M. Nguyen
- Hua Lou
Organizations
- Case Western Reserve University
- National Institutes of Health
- United States Department of Defense