Lipid‐derived aldehyde, acrolein, is a critical mediator of alcohol‐induced gut‐liver injury (653.14)
Abstract
Alcohol is the most socially accepted addictive drug which leads to alcoholic liver disease (ALD), a major cause of morbidity/mortality in the United States. Chronic alcohol consumption, commonly associated with cigarette smoking, causes a pro‐oxidant environment in the liver and increases lipid peroxidation. Acrolein (ACR) is the most reactive and hepatotoxic aldehyde metabolite generated via lipid peroxidation, and is a major component of cigarette smoke. This study investigates the pathogenic role of acrolein as a major mediator of intestinal barrier dysfunction and hepatic endoplasmic reticulum (ER) stress and injury, which are recognized etiologic factors in ALD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.653.14
Entities
People
- Craig Mcclain
- Jingwen Zhang
- Shirish Barve
- Swati Joshi‐barve
- Wei Yang Chen
Organizations
- Louisville VA Medical Center
- National Institutes of Health
- United States Department of Defense
- University of Louisville