Pathogenic mechanisms in highly active anti‐retroviral therapy‐induced hepatotoxicity: role of phosphodieaterase 4 and ER‐stress (653.7)
Abstract
HIV protease inhibitors (HIV‐PIs) are the major components of HAART and have been successfully used in the treatment of HIV‐1 infection in the past two decades. However, it has been shown that HIV‐PIs induce endoplasmic reticulum (ER) stress response and subsequent activation of unfolded protein response leading to dys‐regulation of hepatic lipid metabolism and hepatotoxicity. Our recent work shows that PDE4/cAMP metabolism plays a significant role in alcohol‐induced hepatic steatosis and injury. Hence in the present study, we examined the mechanisms underlying HIV‐PI induced hepatic ER stress and toxicity with a particular emphasis on PDE4 family of enzymes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.653.7
Entities
People
- Craig Mcclain
- David Barker
- Hridgandh Donde
- Leila Gobejishvili
- Priyanka Barve
- Shirish Barve
- Swati Joshi‐barve
Organizations
- Louisville VA Medical Center
- National Institutes of Health
- United States Department of Defense
- University of Louisville