Co‐administration of Neptazane and aminophylline to men abrogates the decline in endurance exercise performance in simulated high‐altitude (708.6)
Abstract
During a sojourn to high altitude, endurance exercise performance is diminished; pharmacotherapy may abrogate this performance deficit. We hypothesized oral administration of Neptazane (N), Aminophylline (A), and/or N combined with A would attenuate hypoxia‐mediated decrements in endurance exercise performance in humans. Healthy males (26±1 years, body mass index: 24.9±0.4 kg/m2; mean±SE) were randomly assigned to one of four treatments: placebo (n=9), N (250 mg; n=10), A (400 mg; n=9), or N (250 mg) combined with A (400 mg; n=8). On two separate occasions, the first in normoxia (21% O2) and the second in hypoxia (15% O2), participants sat for 4.5 hours before completing a standardized exercise bout (30 min, stationary cycling, 100 W) followed by a time trial (time to cycle 12.5 km). The magnitude of time trial performance decrement in hypoxia did not differ (P>0.09) between placebo (+3.0±1.0 min), N (+1.4±0.5 min) and A (+1.8±0.4 min), however the performance decrement with N combined with A was less than placebo (+0.6±0.5 min; P=0.01). This improvement may have been partially mediated by increased SpO2 in hypoxia with N combined with A, compared with placebo (73±1 vs. 79±2%; P<0.02). In adult men, N combined with A abrogated the hypoxia‐mediated decrement in endurance exercise performance. Co‐administration of N and A may promote endurance exercise performance during a sojourn to high altitude.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.708.6
Entities
People
- Christopher Bell
- David Irwin
- Dennis Larson
- Gary Luckasen
- Gregory Giordano
- Hunter Paris
- Joseph Beals
- Karyn Hamilton
- Kyle Sevits
- Laurie Biela
- Rebecca L Scalzo
- Scott Binns
- Thies Schroeder
Organizations
- Colorado State University
- Defense Advanced Research Projects Agency
- Duke University School of Medicine
- University of Colorado Denver