Prostate Cancer Aggressiveness is Positively Associated with Oxidative Stress and Inversely Associated with Plasma Total Antioxidant Capacity (LB371)
Abstract
Prostate cancer (PCa) is the most common non‐cutaneous cancer in men in the US. Although the causes for PCa have yet to be determined, oxidative stress (OS) may be involved. In this study, urinary 8‐isoprostane and plasma total antioxidant capacity (TAC) were measured in a subsample of research subjects (n = 261 plasma, 279 urine) in the North Carolina‐Louisiana Prostate Cancer Project to determine the association between OS, TAC, and PCa aggressiveness. Compared with low and intermediate aggressive cases of PCa, high aggressive cases were found to have lower plasma TAC (mean: 366 vs 610 mM Trolox, n = 22 vs. 239; Wilcoxon rank test, P = 0.05) and higher urinary 8‐isoprostane levels (mean: 177 vs. 147 ng/mmol creatinine, n = 27 vs. 252; log transformed, t‐test, P < 0.05). Plasma TAC was negatively correlated with urinary 8‐isoprostane levels (ρ = ‐0.15; P < 0.05). In simple logistic regression models of high vs. low and intermediate aggressive cases, PCa aggressiveness was negatively associated with TAC, T3 vs. T1 OR=0.19 (95% CI, 0.04, 0.88; P < 0.05), and positively associated with urinary 8‐isoprostanes, T3 vs. T1 OR=3.16 (95% CI, 0.97, 10.30; P = 0.06). These findings suggest that the body’s compromised antioxidant defense and oxidative stress may contribute to PCa aggressiveness.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2014
- Source ID
- 10.1096/fasebj.28.1_supplement.lb371
Entities
People
- Elizabeth T. H. Fontham
- Gissou Azabdaftari
- James L Mohler
- Jeannette T. Bensen
- L. Joseph Su
- Ming‐hui Chen
- Ock K. Chun
- Sang Gil Lee
- Sung I. Koo
- Terrence M. Vance
Organizations
- Louisiana State University
- National Cancer Institute
- Roswell Park Comprehensive Cancer Center
- United States Department of Defense
- University of Connecticut
- University of North Carolina at Chapel Hill