Rat triple perfused in situ preparation for studying the interaction of carotid body, brainstem and spinal cord chemoreceptors
Abstract
The primary roles of the cardiorespiratory system are to oxygenate tissue and remove carbon dioxide. When blood oxygenation falls, breathing accelerates and the sympathetic nervous system kicks into high gear, increasing heart rate and blood pressure and redirecting oxygenated blood to vital organs including the brain. Without carotid body and aortic chemoreceptors the respiratory response to acute hypoxia is obliterated ‐‐ demonstrating that arterial chemoreceptors are responsible for the lion's share of the breathing responses ‐‐ but much of the cardiovascular response remains.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2016
- Source ID
- 10.1096/fasebj.30.1_supplement.1299.11
Entities
People
- Arijit Roy
- Mathias Dutschmann
- Michael B Harris
- Richard J.a. Wilson
Organizations
- Alberta Innovates – Health Solutions
- Canadian Institutes of Health Research
- Florey Institute of Neuroscience and Mental Health
- Hotchkiss Brain Institute, University of Calgary
- Institute of Arctic Biology
- University of Calgary