Network Analytics: Evolutionary Compression, Diffusion and the Action Equation for Mutations
Abstract
Data integration is essential to overcome the current logjam of high throughput data and publications. Here, we show an approach that twins networks with evolution. In malaria, in p53 biology and in head and neck cancer, early studies demonstrate drug target identification and disease stratification. More broadly, these studies shed new light on the genotype‐phenotype relationship and on the impact of mutations, essential steps towards personalized medicine.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2016
- Source ID
- 10.1096/fasebj.30.1_supplement.255.1
Entities
People
- Olivier Lichtarge
Organizations
- Defense Advanced Research Projects Agency
- National Institutes of Health