Individual Amino Acids Differentially Regulate Paracellular Calcium Flux across an Intestinal Cell Model
Abstract
Acute high protein intake results in increased intestinalcalcium absorption in humans and animals. Calcium is absorbed through both passive paracellular and facilitated trans cellular pathways. In rats, the increase in intestinal calcium absorption observed during a high protein dietis mediated at least in part through increased apical intestinal calcium uptake suggesting involvement of the transcellular pathway. However, we previously found that the expression of a paracellular calcium‐permissive tight junction protein, Claudin‐2, is higher in the duodenum of rats consuming a high compared to lowprotein diet. Whether dietary protein affects paracellular calcium flux has not been evaluated. Furthermore, the bioactive amino acids that might underlie this effect have not been identified. The purpose of this study was to evaluate the direct effects of mixed and individual amino acids on paracellular calcium flux across a small intestinal absorptive cell model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2016
- Source ID
- 10.1096/fasebj.30.1_supplement.918.7
Entities
People
- Chris Cummings
- Erin Gaffney‐stomberg
- James Mcclung
- Michael Macarthur
- Phillip Marszewski
- Ronald Matheny
Organizations
- United States Army Medical Research and Development Command
- United States Army Research Institute of Environmental Medicine