Van‐Gogh‐Like 2, Frizzled, and Knypek Control Distinct Aspects of Polarized Cellular Migration During Neural Convergence
Abstract
The planar cell polarity (PCP) pathway plays a significant role in facilitating neural convergence (NC) – the narrowing of the neural plate before the formation of the neural tube. Evidence from the literature and our laboratory suggests that NC in zebrafish requires elongation and midline‐directed polarized migration of neural plate cells. Failure of NC or delayed stages of neural tube morphogenesis can result in severe neural tube defects (NTDs) which have been observed in all vertebrates studied. Although perturbation of the PCP pathway is associated with NTDs in model organisms and humans, the underlying neural cell behaviors remain elusive.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.1006.7
Entities
People
- Eudorah Vital
- Jonathan Werner
- Karndeep Singh
- Rachel Brewster
- Rebecca Mcfarland
- Sharlene Brown
- Stephanie Sanchez
Organizations
- National Institutes of Health
- National Science Foundation
- United States Department of Defense
- University of Maryland, Baltimore County