Poloxamer 188 Improves Autoresuscitation in Pigs with Severe Traumatic Hemorrhage
Abstract
Poloxamer 188 (P188) is a copolymer surfactant. Its protective effects against ischemic injury, cardiomyopathy, and intracerebral hemorrhage have been shown in studies from rats and mice. The underlying protective mechanisms are unclear. This study investigated its effects on blood volume in pigs after severe traumatic hemorrhage and hypotensive resuscitation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.1012.22
Entities
People
- Hui Xia
- Michael A. Dubick
- Wenjun Martini
Organizations
- United States Army Institute of Surgical Research
- United States Army Medical Research and Development Command