Effects of Intranasal NPY on Cardiovascular Parameters and Activity in SPS Model of PTSD: Telemetric Studies
Abstract
Single prolonged stress (SPS) is a rodent model of PTSD with high construct and face validity. Our previous studies revealed that early intervention with neuropeptide Y (NPY) delivered to the brain by intranasal pathways is very effective to prevent development of many of the SPS‐elicited impairments in behavioral and neuroendocrine functions, demonstrating its therapeutic potential. However, there are conflicting findings regarding the effect of NPY on the cardiovascular system. On one hand, NPY is co‐released with norepinephrine from the sympathetic nerve terminals in the periphery and can enhance norepinephrine's vaso constrictive effects. On the other hand several studies indicate that delivery of NPY to selective brain regions may elicit hypotensive effects.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.1088.2
Entities
People
- Charles L Stier
- Esther L Sabban
- Lidia Serova
- Robert L Camp
Organizations
- New York Medical College
- United States Army