The Nrf2 Transcription Factor Promotes Efferocytosis by Activating Phosphatidyl Serine Receptor Tim‐4 Signaling during Oxidant‐Induced Lung Injury Repair
Abstract
Apoptotic cell clearance by macrophages (known as efferocytosis) is critical for the cessation of inflammatory responses and efficient tissue repair post injury. The Nrf2 transcription factor induces the expression of several cytoprotective genes in response to oxidant and toxicant stimuli. We have previously demonstrated that Nrf2‐deficiency impairs the resolution of hyperoxic lung injury, which was accompanied by epithelial cell death and persistent lung inflammation in mice. Here, we tested whether Nrf2 regulates efferocytosis mediated by alveolar macrophages (AMΦs) by upregulating the expression of phosphatidyl serine (PS) receptors that recognizes and internalizes the dead cells, and thereby resolves pro‐oxidant (hyperoxia)‐induced lung inflammation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.470.3
Entities
People
- Chandramohan R Tamatam
- Narsa M Reddy
- Sekhar P Reddy
Organizations
- Naval Medical Research Center
- Otho S. A. Sprague Memorial Institute
- University of Illinois at Chicago