Alveolar Macrophage Heterogeneity As A Driver Of Age‐Related Responses To Influenza A Infection
Abstract
Seasonal influenza A virus infection causes at least 20,000–50,000 deaths in the United States each year and causes disproportionate morbidity and mortality in older individuals. We and others have found similarly disproportionate mortality in aged mice infected with influenza A. An important role for alveolar macrophages in the response to influenza A infection is recognized. Strategies to therapeutically target alveolar macrophages during lung injury have considered that they are a single population of monocyte‐derived cells. This paradigm has been challenged by studies that identified tissue‐resident alveolar macrophages (TR‐AM) as highly specialized cells that populate the lung shortly after birth and persist over the lifespan.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.60.4
Entities
People
- Alexander V. Misharin
- Alexandra Cristina Mcquattie‐pimentel
- Ching‐i Chen
- G.r. Scott Budinger
- Harris Perlman
- James M. Walter
- Karen Ridge
- Luisa Morales‐nebreda
- Monica Chi
- Paul A Reyfman
Organizations
- United States Department of Defense