Disease Specific Signatures Identified by RNA‐seq of Sorted Lung Cellular Populations
Abstract
Fibrotic interstitial lung disease (ILD) is among the top indications for patients undergoing lung transplantation worldwide. While our group and others have demonstrated a role for monocyte‐derived alveolar macrophages in the development of lung fibrosis in murine models, it is unknown if human alveolar macrophages play a similar role in the development of fibrotic ILD. We hypothesized that transcriptional profiling of AMs isolated from lung transplant donors and recipients as well as from murine alveolar macrophages in a bleomycin‐induced lung fibrosis model would demonstrate homology of involved genes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.656.4
Entities
People
- Alexander V. Misharin
- Alexandra Mcquattie‐pimentel
- Ankit Bharat
- Ching‐i Chen
- Debbie Winter
- Elizabeth T. Bartom
- Francisco Gonzalez
- G.r. Scott Budinger
- Harris Perlman
- Hiam Abdala‐valencia
- Jacob I Sznajder
- James M. Walter
- Karen M. Ridge
- Kishore R Anekalla
- Louisa Morales‐nebreda
- Luis An Amaral
- Malcolm M Decamp
- Matthew Antalek
- Monica Chi
- Navdeep S. Chandel
- Neda Bagheri
- Paul A Reyfman
- Philip J. Homan
- Richard I. Morimoto
- Sangeeta M. Bhorade
- Saul Soberanes
- Stephen F Chiu
- Tyrone J. Yacoub
- William Balch
Organizations
- Northwestern University
- Scripps Research
- United States Department of Defense