Polyphosphate‐conjugated Silica Nanoparticles (polyP‐SNPs) Attenuate Bleeding After Tail Amputation
Abstract
Hemorrhage control is a major focus in treating critically injured trauma patients. Uncontrolled blood loss accounts for 25–30% of civilian deaths and the vast majority of all battlefield deaths. Acute traumatic coagulopathy (ATC) occurs in 25–40% of patients nearly immediately after injury and is associated with worsened bleeding, increased need for transfusion, and a 4‐fold increase in mortality. Stopping bleeding and correcting coagulopathy remain the key goals in trauma treatment. Unfortunately, there are few current treatments, and the ones that exist are inadequate due to ineffectiveness, side effects, steep cost per dose, and need for refrigeration. Biomaterials can bridge the critical time between injury and treatment to begin treatment quicker and improve the condition of trauma patients upon hospital arrival. One such potential solution is created by coating a silica nanoparticle (SNP) with a heterogeneous 70‐mer polymer polyphosphate (polyP) chain to form polyP‐SNP.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.674.13
Entities
People
- Damien Kudela
- Galen D Stucky
- Kyle Ploense
- Scott R. Hammond
- Tod E. Kippin
Organizations
- Defense Advanced Research Projects Agency
- University of California, Santa Barbara