Studies on HIV‐1 RNA‐protein interactions.
Abstract
In the absence of a cure and a vaccine, the human immunodeficiency virus (HIV‐1) continues to affect millions of people worldwide. HIV is a retrovirus, a unique family of viruses that replicate via a DNA intermediate. The newly replicated HIV RNA must be spliced in order for it to exit the nucleus of the host cell and be packaged into new viral particles. Normally, unspliced or partially spliced HIV RNA's are trapped within the nucleus and degraded. To combat this, HIV has evolved an accessory protein, Rev. The protein Rev binds to the RRE (located on the unspliced or partially spliced RNA) in order to create a complex that allows for the unspliced HIV RNA genome to be exported out of the nucleus.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.912.14
Entities
People
- Eryn Stockdale
- Ina P O'Carroll
- Kenneth Wise
- Nicole Hadler
Organizations
- Defense Threat Reduction Agency
- United States Naval Academy