Anticonvulsant drug polytherapy stops status epilepticus and prevents neuronal loss in soman‐exposed rats
Abstract
When treatment of status epilepticus(SE) is delayed, seizures become self‐sustaining and refractory to benzodiazepine therapy. Chemical warfare nerve agents (CWNAs), such as soman(GD), increase acetylcholine through inhibition of acetylcholine sterase and can lead to SE if seizures are not treated quickly and controlled. Prolonged seizures may lead to extensive neuropathology, spontaneous recurrent seizures and long‐term performance deficits. To identify a better treatment against pharmacoresistant seizures caused by GD exposure, we are using combinations of drugs aimed at reversing the effects of maladaptive receptor trafficking that follows CWNA exposure.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2017
- Source ID
- 10.1096/fasebj.31.1_supplement.lb629
Entities
People
- Brenda Marrero‐rosado
- Caroline R. Schultz
- Claude G Wasterlain
- Erica Kundrick
- Franco Rossetti
- Jerome Niquet
- Katie Walker
- Lucille A. Lumley
- Michael Stone
- Sean O'brien
Organizations
- National Institutes of Health
- Oak Ridge Institute for Science and Education
- United States Army Medical Research Institute of Chemical Defense
- United States Army Medical Research and Development Command
- United States Department of Energy
- University of California, Los Angeles
- Walter Reed Army Institute of Research