Neuropharmacology of the Dorsal Root Entry Zone
Abstract
The finding of a number of peptides in the central nervous system and the discovery of the endogenous opiates represent major recent advances in the understanding of neural transmission. A number of these neuropeptides are found in the dorsal root entry zone and may play a role in pain. An analysis of changes in distribution of substance P, methionineenkephalin, and somatostatin after simulated nerve root avulsion injury suggested a possible mechanism for deafferentation pain. A review of the localizations and actions of these peptides in the dorsal root entry zone is included.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 1984
- Source ID
- 10.1097/00006123-198412000-00026
Entities
People
- Major Bennett Blumenkopf
Organizations
- San Antonio Military Medical Center