Memories replayed: reactivating past successes and new dilemmas
Abstract
Our experiences continue to be processed ‘offline’ in the ensuing hours of both wakefulness and sleep. During these different brain states, the memory formed during our experience is replayed or reactivated. Here, we discuss the unique challenges in studying offline reactivation, the growth in both the experimental and analytical techniques available across different animals from rodents to humans to capture these offline events, the important challenges this innovation has brought, our still modest understanding of how reactivation drives diverse synaptic changes across circuits, and how these changes differ (if at all), and perhaps complement, those at memory formation. Together, these discussions highlight critical emerging issues vital for identifying how reactivation affects circuits, and, in turn, behaviour, and provides a broader context for the contributions in this special issue.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 06, 2020
- Source ID
- 10.1098/rstb.2019.0226
Entities
People
- Edwin M Robertson
- Lisa Genzel
Organizations
- Air Force Office of Scientific Research
- Dutch Research Council
- Radboud University Nijmegen
- University of Glasgow