Coordinated activities of retrosplenial ensembles during resting-state encode spatial landmarks
Abstract
The brain likely uses offline periods to consolidate recent memories. One hypothesis holds that the hippocampal output provides a unique, global linking or ‘index’ code for each memory, and that this code is stored in the cortex in association with locally encoded attributes of each memory. Activation of the index code is hypothesized to evoke coordinated memory trace reactivation thus facilitating consolidation. Retrosplenial cortex (RSC) is a major recipient of hippocampal outflow and we have described populations of neurons there with sparse and orthogonal coding characteristics that resemble hippocampal ‘place’ cells, and whose expression depends on an intact hippocampus. Using two-photon Ca 2+ imaging, we recorded ensembles of neurons in the RSC during periods of immobility before and after active running on a familiar linear treadmill track. Synchronous bursting of distinct groups of neurons occurred during rest both prior to and after running. In the second rest epoch, these patterns were associated with the locations of tactile landmarks and reward. Complementing established views on the functions of the RSC, our findings indicate that the structure is involved with processing landmark information during rest.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 06, 2020
- Source ID
- 10.1098/rstb.2019.0228
Entities
People
- Adam R. Neumann
- Bruce L. McNaughton
- HaoRan Chang
- Ingrid M. Esteves
- Jianjun Sun
- Majid H Mohajerani
Organizations
- Defense Advanced Research Projects Agency
- Institute of Neurosciences, Mental Health and Addiction
- Natural Sciences and Engineering Research Council
- University of California
- University of Lethbridge