An increase in p62/NBR1 levels in melioidosis patients of Sri Lanka exhibit a characteristic of potential host biomarker
Abstract
Introduction. Melioidosis, caused by Burkholderia pseudomallei , in endemic areas, poses a challenge for treating the diseased populations without accurate diagnosis, and the disease-specific biomarkers linked with the infection have yet to be reported. Due to the invasive nature of the causative agent, Burkholderia pseudomallei , host innate effector mechanisms, including autophagy are known to be activated, resulting in differential expression of cellular proteins and immune markers. Identification of a disease-specific biomarker associated with B. pseudomallei infection will be helpful to facilitate rapid confirmation of melioidosis, which would enable early treatment and therapeutic success.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2020
- Source ID
- 10.1099/jmm.0.001242
Entities
People
- Aruna Dharshan De Silva
- Cyra M. Ranji
- Enoka M Corea
- Kamal U. Saikh
- Mohan Natesan
- Robert G Ulrich
Organizations
- Defense Threat Reduction Agency
- United States Army Medical Research Institute of Infectious Diseases
- University of Colombo