Enhancedin VivoBlood Brain Barrier Transcytosis of Macromolecular Cargo Using an Engineered pH-sensitive Mouse Transferrin Receptor Binding Nanobody
Abstract
The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos with variable efficiency. Transcytosis involves trafficking through acidified intracellular vesicles, but it is not known whether pH-dependent unbinding of transport shuttles can be used to improve blood brain barrier transport efficiency.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 27, 2023
- Source ID
- 10.1101/2023.04.26.538462
Entities
People
- Caroline M. Francescutti
- David L. Brody
- Elvira Rodionova
- Joong Hee Kim
- Shiran Su
- Thomas J Esparza