Tau accumulation and its spatial progression across the Alzheimer’s disease spectrum

Abstract

The spread of tau abnormality in sporadic Alzheimer’s disease is believed typically to follow neuropathologically defined Braak staging. Recentin-vivopositron emission tomography (PET) evidence challenges this belief, however, as spreading patterns for tau appear heterogenous among individuals with varying clinical expression of Alzheimer’s disease. We therefore sought better understanding of the spatial distribution of tau in the preclinical and clinical phases of sporadic Alzheimer’s disease and its association with cognitive decline.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 05, 2023
Source ID
10.1101/2023.06.02.23290880

Entities

People

  • Alexa Pichet Binette
  • Frédéric St‐Onge
  • John Cs Breitner
  • Marianne Chapleau
  • Sylvia Villeneuve
  • The Alzheimer’s Disease Neuroimaging Initiative*

Tags

Readers

  • Medical Imaging.
  • Systems Analysis and Design
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.