Circulating lipid profiles are associated with cross-sectional and longitudinal changes of central biomarkers for Alzheimer’s disease
Abstract
Investigating the association of lipidome profiles with central Alzheimer’s disease (AD) biomarkers, including amyloid/tau/neurodegeneration (A/T/N), can provide a holistic view between the lipidome and AD. We performed cross-sectional and longitudinal association analysis of serum lipidome profiles with AD biomarkers in the Alzheimer’s Disease Neuroimaging Initiative cohort (N=1,395). We identified lipid species, classes, and network modules that were significantly associated with cross-sectional and longitudinal changes of A/T/N biomarkers for AD. Notably, we identified the lysoalkylphosphatidylcholine (LPC(O)) as associated with “A/N” biomarkers at baseline at lipid species, class, and module levels. Also, GM3ganglioside showed significant association with baseline levels and longitudinal changes of the “N” biomarkers at species and class levels. Our study of circulating lipids and central AD biomarkers enabled identification of lipids that play potential roles in the cascade of AD pathogenesis. Our results suggest dysregulation of lipid metabolic pathways as precursors to AD development and progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 13, 2023
- Source ID
- 10.1101/2023.06.12.23291054
Entities
People
- Andrew J. Saykin
- Bruce S. Kristal
- Colette Blach
- Gabi Kastenmüller
- Jun Pyo Kim
- Kevin Huynh
- Kwangsik Nho
- Matthias Arnold
- Paula J. Bice
- Peter J. Meikle
- Rebecca Baillie
- Rima Kaddurah-daouk
- Shannon L. Risacher
- The Alzheimer's Disease Metabolomics Consortium
- The Alzheimer’s Disease Neuroimaging Initiative*
- Tingting Wang
- Xianlin Han