Normal gastric tissueHelicobacter pyloriinfection is associated with epigenetic age acceleration, increased mitotic tick rate, tissue cell composition, and Natural Killer cell methylation alterations
Abstract
Gastric adenocarcinomas are a leading cause of global mortality, associated with chronic infection withHelicobacter pylori. The mechanisms by which infection withH. pyloricontributes to carcinogenesis are not well understood. Recent studies from subjects with and without gastric cancer have identified significant DNA methylation alterations in normal gastric mucosa associated withH. pyloriinfection and gastric cancer risk. Here we further investigated DNA methylation alterations in normal gastric mucosa in gastric cancer cases (n = 42) and control subjects (n = 42) withH. pyloriinfection data. We assessed tissue cell type composition, DNA methylation alterations within cell populations, epigenetic aging, and repetitive element methylation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 29, 2023
- Source ID
- 10.1101/2023.06.28.546926
Entities
People
- Brock C Christensen
- Irma Vlasac
- Lucas A. Salas