MGDrivE: A modular simulation framework for the spread of gene drives through spatially explicit mosquito populations
Abstract
Malaria, dengue, Zika and other mosquito‐borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticide‐based tools and antimalarial drugs. The advent of CRISPR/Cas9‐based gene editing and its demonstrated ability to streamline the development of gene drive systems has reignited interest in the application of this technology to the control of mosquitoes and the diseases they transmit. The versatility of this technology has enabled a wide range of gene drive architectures to be realized, creating a need for their population‐level and spatial dynamics to be explored.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 05, 2019
- Source ID
- 10.1111/2041-210x.13318
Entities
People
- Héctor Sánchez
- Jared B. Bennett
- John M Marshall
- Sean L Wu
Organizations
- Defense Advanced Research Projects Agency
- Innovative Genomics Institute