Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
Abstract
Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF‐α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF‐related apoptosis‐inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5‐blocking antibodies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 21, 2016
- Source ID
- 10.1111/acel.12437
Entities
People
- Arthur G. Kristiansen
- Konstantina M. Stankovic
- Shyan‐yuan Kao
- Vitor Y.r. Soares
Organizations
- Fondation Bertarelli
- Harvard Medical School
- United States Department of Defense