Mastering organismal aging through the endoplasmic reticulum proteostasis network
Abstract
The aging process is characterized by a progressive decline in the function of most tissues, representing the main risk factor in the development of a variety of human diseases. Studies in multiple animal models have demonstrated that interventions that improve the capacity to maintain endoplasmic reticulum (ER) proteostasis prolong life and healthspan. ER stress is monitored by the unfolded protein response (UPR), a signaling pathway that mediates adaptive processes to restore proteostasis or the elimination of damaged cells by apoptosis. Here, we discuss recent advances in understanding the significance of the UPR to aging and its implications for the maintenance of cell physiology of various cell types and organs. The possible benefits of targeting the UPR to extend healthspan and reduce the risk of developing age‐related diseases are also discussed.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 31, 2020
- Source ID
- 10.1111/acel.13265
Entities
People
- Claudio Hetz
- Rebecca C Taylor
Organizations
- Buck Institute for Research on Aging
- FONDEF
- Laboratory of Molecular Biology
- Medical Research Council
- Muscular Dystrophy Association
- National Fund for Scientific and Technological Development
- Office of Naval Research